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Document 2608
DOCN M94A2608
TI Vaginal fluid collected with OMNI-SAL collection device as an
alternative to serum for immunodiagnosis.
DT 9412
AU Singh N; Singh S; Deptt of Lab. Medicine, All India Inst. of Medical
Sciences, New; Delhi.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):265 (abstract no. PB0489). Unique
Identifier : AIDSLINE ICA10/94369967
AB INTRODUCTION: Blood collection and processing, for serological diagnosis
of infectious diseases like HIV, HBV, HSV etc. has got potential risk of
hospital acquired infection. Saliva has been advocated as an alternative
of the serum for immunological assays. We further extended this
possibility to vaginal fluids to use it as clinical specimen for TORCH
antibody determination. METHODS: Serum, saliva and vaginal fluids from
25 women (aged 20-30) were tested for TORCH antibody profiles. The
saliva and vaginal fluids were collected using the OMNI-SAL collection
device. The antibody concentration in all the three body fluids were
compared. RESULTS: The antibody concentration in vaginal fluids were
more than saliva but less than serum for Toxoplasma, Rubella, CMV and
HSV infections. However, anti-toxoplasma specific IgA antibody levels
were almost same in vaginal fluids and serum. CONCLUSIONS: Vaginal fluid
can be used as an alternative to the serum. Unlike saliva, in vaginal
fluid, there are no fluctuations in the concentration during eating,
drinking or emotions. Moreover, detection of IgA antibodies in vaginal
fluids is more pertinent in prevention of sexually transmitted diseases.
DE Adult Antibodies/*ANALYSIS Comparative Study Cytomegalovirus
Infections/*IMMUNOLOGY Female Herpes Simplex/*IMMUNOLOGY Human IgA,
Secretory/METABOLISM Predictive Value of Tests Rubella/*IMMUNOLOGY
Saliva/IMMUNOLOGY Toxoplasmosis/*IMMUNOLOGY Vagina/*IMMUNOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).